Deep reinforcement learning for automated radiation adaptation in lung cancer

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141551/1/mp12625.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/141551/2/mp12625_am.pd

Genome-Wide Association Study of Treatment Refractory Schizophrenia in Han Chinese

We report the first genome-wide association study of a joint analysis using 795 Han Chinese individuals with treatment-refractory schizophrenia (TRS) and 806 controls. Three loci showed suggestive significant association with TRS were identified. These loci include: rs10218843 (P = 3.04×10−7) and rs11265461 (P = 1.94×10−7) are adjacent to signaling lymphocytic activation molecule family member 1 (SLAMF1); rs4699030 (P = 1.94×10−6) and rs230529 (P = 1.74×10−7) are located in the gene nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (NFKB1); and rs13049286 (P = 3.05×10−5) and rs3827219 (P = 1.66×10−5) fall in receptor-interacting serine/threonine-protein kinase 4 (RIPK4). One isolated single nucleotide polymorphism (SNP), rs739617 (P = 3.87×10−5) was also identified to be associated with TRS. The -94delATTG allele (rs28362691) located in the promoter region of NFKB1 was identified by resequencing and was found to associate with TRS (P = 4.85×10−6). The promoter assay demonstrated that the -94delATTG allele had a significant lower promoter activity than the -94insATTG allele in the SH-SY5Y cells. This study suggests that rs28362691 in NFKB1 might be involved in the development of TRS

Synthesis and photocatalytic performance of Ag-TiVOX nanocomposite

Abstract: A silver, vanadium and silver/vanadium doped titanium dioxide (TiO2, Ag-TiO2, V-TiO2 and Ag-TiVOX) nanocomposite photocatalyst was achieved via a modify sol–gel and hydrothermal method. Structural analysis by X-Ray Diffraction (XRD) depicted the lattice fringes for both anatase and rutile in its crystalline phase in the synthesized nanocomposites. Surface areas (SBET) analysis shows that surface area of synthesized Ag-TiVOX is 46.01 m2/g, compare to TiO2 64.75 m2/g, Ag-TiO2 61.33 m2/g and V-TiO2 62.73 m2/g. Optical absorption results demonstrated by UV–Visible Spectroscopy (UV–Vis) shows that the effects of Ag and V doping was a shift in spectrum to the visible light region, enhancing the visible light absorption capacity of the synthesized photocatalyst. The optical absorption of Ag-TiVOX achieved a reduced bandgap energy of 2.2 eV, as compared to Ag-TiO2 (2.8 eV), V-TiO2 (2.3 eV) and TiO2 (2.9 eV). Morphological characterization by Transition Electron Microscope (TEM) and Scanning Electron Microscope (SEM), depicting a cluster composed of spherical aggregates particles of non-uniform diameter nanoparticles with particle size ranging between 10 and 50 nm. Synthesized Ag-TiVOx demonstrated remarkable photocatalytic capabilities under visible light irradiation, as 99.83 percent of methylene blue (MB) degradation was accomplished during the first 15 min. Impact of Ag and V doping of TiO2 showed enhancement in the photocatalytic activity, reporting excellent removal rates and achieving well desirable decline in the band gap energy

The emerging role of TGF-β superfamily coreceptors in cancer

20 páginas, 6 figuras, 2 tablas.The transforming growth factor beta (TGF-beta) signaling pathway plays a key role in different physiological processes such as development, cellular proliferation, extracellular matrix synthesis, angiogenesis or immune responses and its deregulation may result in tumor development. The TGF-beta coreceptors endoglin and betaglycan are emerging as modulators of the TGF-beta response with important roles in cancer. Endoglin is highly expressed in the tumor-associated vascular endothelium with prognostic significance in selected neoplasias and with potential to be a prime vascular target for antiangiogenic cancer therapy. On the other hand, the expression of endoglin and betaglycan in tumor cells themselves appears to play an important role in the progression of cancer, influencing cell proliferation, motility, invasiveness and tumorigenicity. In addition, experiments in vitro and in vivo in which endoglin or betaglycan expression is modulated have provided evidence that they act as tumor suppressors. The purpose of this review was to highlight the potential of membrane and soluble forms of the endoglin and betaglycan proteins as molecular targets in cancer diagnosis and therapyThis work was supported by grants from the Spanish Ministry of Science and Innovation (SAF2007-61827 to CB, SAF2007-63821 to MQ, and SAF2007-63893 to JML-N), the Instituto de Salud Carlos III (ISCIII-CIBER CB/06/07/0038 to CB), and the Red de Investigacion en Enfermedades Renales (ISCIII-RD06/0016 to JML-N) of Spain.Peer reviewe